Little more understanding on Glutathione. (Information compiled by Tamara Leetun)
💯Fact #1: Glutathione is found in food- but it is oxidized in the digestive tract before the body has the chance to use it entirely. [https://www.ncbi.nlm.nih.gov/pubmed/25198144](https://www.ncbi.nlm.nih.gov/pubmed/25198144…)
💯Fact #2: Sublingual glutathione is better than tablet/capsules (and it is 488% more expensive than the oral version and only 230% more effective). [https://www.ncbi.nlm.nih.gov/pubmed/26262996](https://l.facebook.com/l.php…)
💯Fact #3: Glutathione is made from three amino acids (glutamate, cysteine, and glycine) somehow we’ve made the leap to think that NAC (N-acetyl-cysteine) will help us produce glutathione but where’s the glycine?
💯Even studies suggesting NAC is useful in glutathione synthesis point back to NRF2
“The other key determinant of the rate of glutathione synthesis is the expression of gamma-glutamylcysteine synthetase, a phase 2 enzyme whose transcription is stimulated by activation of the nuclear factor (erythroid-derived 2)-like 2 (nrf2) transcription factor.54 55 A wide range of nutraceuticals and drugs, characterised as ‘phase 2 inducers’, are known to activate nrf2, leading to induction of a range of antioxidant enzymes, as well as gamma-glutamylcysteine synthetase. Perhaps, the most clinically developed of these is the natural cofactor lipoic acid (transported most effectively as its natural R-isomer56), which has documented clinical utility in diabetic neuropathy when administered at 1200–1800 mg daily—a clinical dose range similar to that of NAC.4 ,5 , 57– ,5 ,9 In ageing rats, oral administration of R-lipoic acid has been shown to boost myocardial glutathione levels, while decreasing those of ceramide60—an effect likely attributable to inhibition of NSMase-2. Lipoic acid has likewise been shown to diminish ceramide levels and the activities of NSMase-2 and PP2A in endothelial cells in vitro.61”
💯Fact #4: The best dose to take to boost glutathione is still debatable. 250 mg improved glutathione levels in this study (but didn’t seem to have any impact on wellness) but so did the 1000 mg dose (sometimes). [https://www.ncbi.nlm.nih.gov/pubmed/24791752](https://l.facebook.com/l.php…)
💯Fact #5: You might improve your glutathione status somewhat by taking the most expensive liposomal glutathione you can find that has also been evaluated in a clinical or peer-reviewed study but that is all that oral supplement will provide you–the potential to increase your glutathione status.
💯Fact #6: Our Nrf2 synergizer was specifically studied and was found to **significantly increase** total glutathione. What does that mean? It means it DOES work for everyone. There’s no guessing and it’s only $49.99 per month. [https://www.ncbi.nlm.nih.gov/pubmed/19056485](https://l.facebook.com/l.php…)